Protective Effect of Sodium Selenite on the Reproductive System of White Male Rats Exposureto Oxidative Stress Induced by Hydrogen Peroxide

Abstract

The study focused on two aspects: the effect of hydrogen peroxide on the levels of Spermatogonium, Speratocytes, Spermatids, Leydig cells, and Sertoli cells, the oxidation system of Glutathione and Catalase, on the Malondialdehyde (MDA), and its effect on testicular tissues in white male rats And to study the protective effect of the antioxidant sodium selenate , 21 adult male rats were used and randomly divided into three equal groups. The control group was fed a standard diet and drank water that was free of hydrogen peroxide, the treatment group T1 was fed a standard diet and given water laced with 0.5% hydrogen peroxide and treatment group (T2) given 0.5 mg/kg diet sodium selenate as part of their diet (Soudani et al., 2012) and given water laced with0.5%  hydrogen peroxide.

The findings revealed that hydrogen peroxide had a significant effect on the reproductive system and that the antioxidant sodium selenate had a significant effect in reducing the oxidative stress caused by hydrogen peroxide.