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Crude extract of Anastatica hierochuntica L was analyzed for active compounds and tested for its effect on the body of laboratory mice and their fertility. Data obtained showed that the extract contained saponins, flavonoids, alkaloids and terpens. Test period lasted for a year included 60 mice each time that were divided into 6 groups. Each group was administered orally with 100, 200, and 300 mg/kg of the plant extract, control group positive (vitamin C and E) and control group negative (water and DMSO). Results of histology examination showed no toxic effect on liver and kidney of treated animal even with prolonged administration, while there is an elevated level of testosterone hormone and an increase in sperm count with increased body mass index of 2%.