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The present study was done in the Kufa University / Science College from aimed to investigate the potential effect of marjoram oil as an anti-bacterialagent for Staphylococcus aureusbacteria and study the synergism action on the vital organs which include (liver, kidney, and spleen) in male rats. twelve adult male rats were divided into four groups include three rate in every group:
Group 1 : processed with normal slain for a two week.
Group 2: processed with (0.1) bacterial suspension.
Group 3: processed with (0.1) bacterial suspension and after one day processed with essential oil ofO.majorana (0.16ml /kg) for a two week.
Group 4: processed with essential oil of O.majorana(0.16ml/ kg) for a two week.
The histological inspection of our study show histopathological changes on G 2 that treated with bacterial suspension compared with control group (G1) represented by granuloma like lesion, aggregation of lymphocyte in Liver, degeneration in the kidney tubule, fibrosis and Spleen white pulp hyperplasia, moreover the biochemical assay showed large change in the value of ALP levels ( alkaline phosphatase), urea , creatinine , and ASAT level (aspartate aminotransferase).
In the G3 that treated with bacteria and oil was shows focal degeneration of portal triad, inflammatory cell and apoptotic bodies in liver, whereas the Kidney demonstrated the haylincast (pyelonephritis) while there was no any changes in the spleen and the biochemical study reported that little changes in the value of ALP levels, urea, creatinine and ASAT levels. As for G4 that treated with oil only, our results demonstrated normal effects in the Kidney,liver hepatocyte and tissue of spleen, and showed no any changes in value of (ALP), urea, Creatinine, (ASAT) and (ALAT).