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The metabolic alternations related to obesity are a serious risk factors that leads to many health problems. The aim of the study is to estimate some biochemical and hormonal parameters in the blood of obese females with different distribution of body fat.Methods:premenopausal healthy females (n=148) that have various body weight and aged (39-43 years), which were assessed their obesity by BMI and the regional body fat by the WC, WHR and WHtR parameters. The Navy seal formula were used to detect body composition. Blood biochemical, insulin, cortisol, thyroid hormones, total testosterone, visfatin, IL8 and CRP were tested in the serum. Results: according to WC and WHR, the obese females (n=83) revealed two types of obesity, the central and peripheral obesity. The Navy formula showed high significant fat ratio and fat mass particularly in central obesity females. The serum of obese category showed significant increasing in fasting glucose, insulin, HOMIR with dyslipidemia. The serum cortisol, total testosterone, visfatin, IL8 and CRPwere also elevated in obese females with significant differences in central obesity group than the peripheral obesity group. Compared to normal weight females, the obese females revealed significantincreasing in TSH and FT3 levels while the FT4 was insignificant. Conclusion: the obesity in healthy females especially the central obesity type was associated with alternations in serum profiles of somehormonal and inflammatory biomarkers.