Boosting Immune System: Camel Milk Alleviation of Abnormal Growth and Fertility System Changes Induced by Gamma Radiation in Male Albino Rats

Abstract

Radiotherapy is one of the essential therapeutic modalities for tumors treatments, but it has some influences on the healthy tissues. The aim of the present study is the evaluation of the efficacy of camel milk ingestion against gamma-radiation, induced abnormality in growth, and serum immunoglobulin and sperm system of male albino rats. Methods of this work: Ninety six of healthy male albino rats were classified into 16 groups and ingested with camel milk doses for 35 days after gamma-irradiation. Collected blood serum was used for biochemical determinations (testosterone, glucose, Fructosamine, acid phosphatase and lactate dehydrogenase) and serum immunoglobulin (IgG, IgA and Ig M). Sepermatogenic damages (testes weight, sperm count, epididymis weight (g) and seminal weight (g) were determined. Also, frequencies of morphological sperm abnormalities were examined .Body weight gain, food intake and feed efficiency of each rat of each group were determined. Results: There were significant decrease in the body weight gain, feed efficiency, testes weight and sperm count in gamma radiated rats. The same trend was observed for testosterone, fructosamine contents as well as the activities of acid phosphatase and LDH. The present disturbed observations were dose dependent .Camel milk treatment by ingestion into IRR-rats alleviated the harmful effect of the gamma rays exposure .The growth rates and feed efficiency was improved. The parameters of spermatogenic damage (testes, weight, sperm count, epidydimis weight and seminal weight) were improved. The male fertility parameters also improved by camel milk treatment. Camel milk reduced the disturbed effects of the sperm shaped abnormalities in head and tail. Conclusion: The desirable therapeutic effect of camel milk treatment were dose dependent for all parameters examined.