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This article reveals the analysis of the biological indicators of industrial hybrids belonging to silkworm species Bombyx mori L. and obtained by involving new lines Line 5 labeled, Line 6 labeled, Line 31 labeled and Line 32 labeled on the color of egg and created at Uzbekistan Scientific Research Institute of Sericulture. Due to the easy separation of one component of the hybrids into the sex, it is possible to reduce the costs of egg production in the silkworm egg-producing plant by 50%. In addition, the combinations involved in hybridization allow the production of full industrial hybrids with cocoon productivity. As a result of three years of comparative testing, ♀ Line 32 lab. x ♂ Line 101 and ♀ Line 101 x ♂ Line 32 lab. combinations showed positive results. When the cocoon yield from 1 box of silkworm was 76.6 kg in a foreign hybrid, ♀ Line 32 lab. x ♂ Line 101 and ♀ Line 101 x ♂ Line 32 lab. hybrids produced 85.9 kg and 92.5 kg yield, respectively.