Method of Using Cystatin C as A Predictor of Early Diagnostics of Diabetic Nephropathy

Abstract

The aim is to evaluate the possibility:The aim of the current study is the feasibility of using cystatin C level and glomerular filtration rate calculated using CKD-EPI_cys and CKD-EPIcreat-_cys formulas in the early diagnosis of diabetic kidney impairment in women with type 1 diabetes in the prep stage and in the first three months of in pregnant women.

Materials and research methods:The study sample consists of 47 women with type 1 diabetes, of whom 25 are pregnant and 22 are planning to become pregnant. For all patients, the level of cystatin C was determined, and the glomerular filtration rate was calculated using the methods of different test formulas (Rehberg, CKD-EPI_cr, CKD-EPI_cys, CKD-EPI_cr-cys), the dosage and regimen of insulin therapy were adjusted, and the training was conducted in a school diabetes.

Results:The results of the study showed that there is a difference between groups of pregnant women and those planning to become pregnant in the level of glycated hemoglobin (p = 0.001), the percentage of creatinine in the blood (p = 0.001), and the glomerular filtration rate calculated on the basis of the Rehberg test (p = 0.017). The formulas were CKD-EPI_cr (p = 0.005) and CKD-EPI_cr-cys (p = 0.046), and were comparable for urine creatinine, cystatin C, glomerular filtration rate determined by the CKD-EPI_cys formula and based on daily protein loss. In the majority of pregnant women, when determining the glomerular filtration rate using the CKD-EPI_cr formula, stage C1 was detected (87.5%) and only 12.5% ​​was stage C2, which differs statistically significantly from the group of patients planning pregnancy, as the percentage of patients who Experienced by comparable C1 and C2 low glomerular filtration rate stages (p = 0.002). When regulating the glomerular filtration rate according to the CKD-EP_cys formula, most pregnant women also have stage C1, while most women who plan to become pregnant have stage C2. Phase C3a was generated in both groups only when calculating the glomerular filtration rate using the CKD-EPI_cys formula. When performing the glomerular filtration rate according to the Reberg test, most women from both groups were classified as stage C1, and the percentage of women with stages C1 and C2 in groups planning pregnancy and pregnant women did not differ significantly.