Correlation between IL 2, IL21 and IFNAR1 in Patients with Multiple Sclerosis and Healthy Controls

Abstract

Regarding the duration of multiple sclerosis and patients divided into two groups ≤ 5 years and > 5 years, the largest number of diseases was (≤ 5years), high significance differences at (P ≤ 0.01). The MS patients were distributed according to EDSS which ranged between (≤ 3) and (> 3) high significance differences at (P ≤ 0.01), the patients were 61 (87.14%). The current study reported that serum level of IL-2 revealed high significant differences at (P ≤ 0.01), (1013.14 ± 391.95 vs. 267.2318 ± 207.76) pg/ml) for patients and controls respectively. Measurement of IFNAR serum level show high significant decrease (791.613 ± 544.066 vs. 1352.995 ± 491.284) pg/ml for patients and controls respectively. While the serum level of IL-21 noted that no significant deference at (P ≤ 0.05) of 70 MS patients (104.851± 268.660 pg/ml) compared with healthy controls of 50 were (68.214± 9.054pg/ml). Regarding, correlation between all study markers WBC types and Interleukins (IL-2, IL-21 and IFNAR) of patients group were explained, positive correlation is observed between Neutrophil and IL21(0.285) at (0.05) level, and positive correlation between Eosinophil and IL-21 and IFNAR (0.241* and 0.270*), respectively. While there was a strong negative relationship between IL-2 and IFNAR which high significant deference correlation (-0.366) at (0.01) level.