Synthesis and Characterization of Some New Formazan- Cefixime and Study of Against Breast Cancer Cells

Abstract

In this study, the starting of synthesis from the esterification of Cefixime of the two carboxylic groups, then its reaction with hydrazine to produce hydrazo cefixime, flowed by reaction with some different aldehydes compounds (R-CHO) to yield imine containing a group (-C=N-) known as azomethine,the last step via more than three reactions fromCoupling and linking with diazo compounds fromgroup (-N=N-) to produce formazan-Cefiximederivatives fromdrugs. All the synthesized compounds studied with spectroscopy techniques (FT.IR, H¹NMR, C¹³HNMR) and were examined to demonstrate chemical bonds, active groups and different environments for their components, and some other chemical properties such as melting point measurement and thin layer chromatography (TLC), in addition to the biomechanical test likebreast cancer (MTT assay).