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COVID-19 virus infection mainly affects the respiratory system and presents with the initial symptoms of fever, cough, and body aches. It has been observed that in cases of corona disease, patients show signs of chronic fatigue after the disease. Chronic Fatigue Syndrome (CFS) is referred to as chronic fatigue caused by diseases and can include long-term symptoms such as deep fatigue, difficulty concentrating, and problems in controlling the autonomic system. Studies show that the cytokine response is effective in causing this problem. The cytokine response is an over-inflammatory process that results in complications such as multiple organ failure. Delayed expression of interferons, as an essential part of the innate defense against viral infections such as COVID-19, plays a key role in creating the "cytokine storm", which is observed in patients with COVID-19. This disruption of the immune system and increased immune response in people with corona disease can lead to chronic fatigue syndrome. But the important point is that chronic fatigue, with changes in neuropsychiatric health, can affect the activity and function of the immune system of people with the disease, predisposing them to other diseases. Paying attention to effective factors and treatments can play an important role in improving the health of people with chronic fatigue syndrome.