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Theexperimental studies suggest that Hepcidin can be a protein participating in the developmentof metabolic disorders, while its synthesis and concentration in the circulation outside of the iron metabolism parameters can be influenced by hormones. The aim of the present study wasperforming experiments to determine the concentrations of a variety of critical variables. represented by Hepcidin , erythropoietin, testosterone and many of blood parameters (hemoglobin, iron, ferritin, red blood cells and PCV) in a group of women with Poly cystic ovary syndrome (PCOs) in Kirkuk city and normal women .Materials and Methods: our study include(55) samples were collected from blood serum of women with the PCOsin age of (18-47) years with a measurement of their BMI ≤ 30 kg/m2, while (25) blood samples were collected from healthy women and they were considered a control group with a BMI ≥22 kg/m2, where samples were collected from volunteer women from Kirkuk hospital and external specialized clinical, after diagnosis by specialized doctor, and the study was conducted from September 2018 to March 2019, the experimental groups were divided to two groups :group 1 patients women with PCOs , group 2 healthy control group.Results: We reach to following conclusions a significant increase (P≤0.01) in the concentrations of testosterone and iron with hemoglobin, red blood cells and PCV in women suffering from polycystic ovaries , but a significant decrease (P≤0.05) in the concentrations of both hepcidin and ferritin in patients, in contrast there no significant change in Erythropoietin concentration for women with PCOS , all these results were compared with the healthy control group.Conclusion:Hepcidin is the essential regulator of general iron homeostasis. Dysregulation of hepcidin production effects in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in iron-loading anemias, , hepatitis C and hereditary hemochromatosis.