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Fluorine is embedded in the structure of the main mineral substance of the tooth tissue – hydroxyapatite, which turns into a much harder fluorohydroxyapatite. Fluoride is especially important for the hardness of the tooth enamel. The recommended daily dose of fluoride is only 0.05 mg / kg, however, with an increase in the dose of fluoride by only 0.01 mg / kg, the risk of fluorosis increases significantly (Nikolishin A.K. 1999). The presence of high concentrations of fluoride in drinking water (1.5-12.0 mg / l) is the main etiological factor of fluorosis. The concentration of fluoride in water up to 0.5 mg / l, as a rule, does not cause any manifestations of fluorosis in the tissues of the teeth.