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Therefore, the aim of the present work is to detect the role of A. lumbricoides in an inducing oxidative stress in young children and their effect on the levels of some antioxidant enzymes. The current work was done among children aged 6 years to 14 years in Al-Hawijacity, Kirkuk, Iraq. 174 children used in current study at March 2019 to December2020. The feces were examined by the direct methodto detect A. lumbricoides. The presentworkexhibited that the number of infected children out of 174 is 23 (13.2%) children with A. lumbricoides. Otherwise, the outcomesshowed that the levels of Malondialdehyde (MDA), Glutathione (GSH), and superoxide dismutase (SOD)and catalase in an infected children show significant (P < 0.05) reduce compared with healthy children. So, the current study show that A. lumbricoides induced oxidative stress and causing disorders in antioxidant enzymes levels, which play important against the reactive oxygen species.