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The article presents the results of follow-up of 30 patients with invasive candidiasis who developed against the background of HIV infection during the period 2019-2021. The features of the clinical course of the disease and the risk factors for its occurrence are described. The clinical picture of invasive candidiasis in HIV-infected patients is similar to that of bacterial sepsis, characterized by a severe course and high mortality. Risk factors are severe immunodeficiency, lack of antiretroviral therapy, and the presence of 2 or more foci of superficial candidiasis. The diagnosis of hematogenic dissemination should be performed in all HIV-infected patients in the presence of supporting symptoms.