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This study was carried out in the green house of the fields of the College of Agriculture and marshes -Thi-qar university- south of Iraq in the year 2018, to determine the impact of pyridoxine (vitamin B6) on the growth and antioxidant enzymes of the wheat plant cultivated under the salinity stress (9.23) milimos. cm-1. The wheat seeds were socked in seven concentrations of pyridoxine (0, 250, 1000, 1750, 2500, 3250, 4000) mg. L-1 , growth traits and antioxidant enzymes (DHAR, GPX and POD) were studied at flowering stage. The output showed significant differences, by increasing the concentration of pyridoxine gradually to 1750 mg. L-1 most of growth traits increased also, then decreased after this concentration.The increasing of pyridoxine (vitamin B6) concentrations to a certain extent (1750) mg. L-1 can protect the plant and increases its resistance to salinity stresses.