Main Article Content
The influence of polycyclic aromatic hydrocarbon and tetra-ethyl lead (TEL) on the gene CYP1A1 is highly widespread, as workers can be exspoused with this material. which is effected through exposure or dealing with it. Therefore, the present study aimed to determining the influence of PAH and the role of CYP1A1 gene according to some criteria (age, smoking, and family history). The current study included 50 workers with highest CYP1A1 lacking of workers 48%compare with control 40%at the level of significant (P≤0.05). DNA was Extracted from the two sets and amplified CYP1A1 gene with of technology of Polymerase Chain Reaction (PCR) so as Albumin gene (internal control). The highest percentage of lacking in heavy smoking51.4% compare with light ones 48.57%. The highest gene CYP1A1 dele tion rate was aged (more than 50) years was (60%).The rate of lacking gene by the family history was 23%and in nob family history was 9% with has significant differences. at the level of significant (P≤0.05).