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This prospective observational study was conducted in department of Obstetrics &GynaecologySreeBalaji Medical College & Hospital, Chennai, from February 2015 to August 2016. The study was conducted on 300 randomly selected antenatal patients attending the antenatal clinic. Out of the 44 patients who had abnormal Serum PAPP-A MoM (<0.5MoM)values, 20(45.5%) patients had uneventful pregnancies, 10(22.7%) patients had gestational hypertension, 7 (15.9%) patients had pre-eclampsia, and 7 (15.9%) patients had fetal growth retardation. The final conclusion of our study is that combined use of uterine artery Doppler with PI and serum PAPP -A has shown increased efficiency, detection rates and decreased false positivity rates in diagnosing cases of pre-eclampsia and PIH in first trimester than using them individually.