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In Ground section there is no need to remove the mineral, so that the bone in the section contains both the mineral and the collagen that form most of the bone structure. Resin embedding can make immunohistochemical antigen detection or DNA isolation for clonal gene rearrangement assays difficult. It gives better nuclear staining and reduces hydrolysis but may damage the tissue. In decalcified section inorganic substance is dissolved and the organic substance remains while in ground section organic substance is burnt and inorganic substance remains. This review is done to compare the ground section, decalcified section and resin embedded section of the bone to determine the better processing for microscopical study of the bone.