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The aim of this review is to determine the most effective treatment for simple extraction and to determine its role in minimizing postoperative complications, patient discomfort and provide better healing. The objective of this review is to assess the better sepsis control for post extraction treatment. The oral cavity has one of the vastest spectrums of bacterial flora in the body. Their increase in number can contribute to local and systemic complications. Their potential to develop infections has made antibiotics as one of the most commonly prescribed drugs in dentistry. Prescription of antibiotics are given after simple tooth extraction and this has remained as a controversial topic amongst dentists. Antibiotics are thought to increase postoperative comfort following extraction by preventing pain and wound infection. Moreover, a mouthwash is a medicated liquid which is held in the oral cavity and swished by the action of the perioral musculature to eliminate the oral pathogens, is also being increasingly prescribed by dentists. As this number increases, the question that frequently arises is which one is better. This aim of this review is asses which is the better treatment option for post extraction.