Antidiabetic Activity of Leaf Extracts of Aegle Marmelos Linn in Streptozotocin - Nicotinamide Induced Diabetic Wistar Albino Rats

Abstract

The presentstudywastoscientificallyinvestigate the traditional claim of Aegle marmelos (A. marmelos)used to subside the symptoms of diabetes mellitus by siddha system of medicine.Hence,thestudywascarriedoutto conformtheactivity.TheplantleavesofA. marmeloswasextractedwith chloroform,ethanol and waterin Soxhlet apparatus. The extractsobtainwere tested for acutetoxicitystudyinwistaralbino mice atdifferentdose. The maximum tolerant dose was observed as 2000mg/kgb.wt.Nomotility andtoxicsymptomswere observed at a dose of 2000mg/kg, b.wt. So, the 1/5 (400mg) of themaximum tolerant dose was selected for the screening of antidiabetic activity. The 14 days antidiabetic treatment reveals that there is a deviation in the biochemicalparameterssuchasaspartateaminotransaminase (AST),alanineaminotransaminase(ALT),alkalinephosphatase(ALP),bloodglucose (BG),cholesterol(TC),totalprotein(TP)andtotalbilirubin(TB).Theethanolic(P<0.001) andwater (P<0.01) extract at a dose of 400mg/kg exhibited significant antidiabetic activity which was compared with the standard drug Gilbenclamide10mg/kg.