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Forty two specimens were gathered from patients suffering from different fungal diseases and from different areas of the body including skin, hair, nails and mouth. Five types of fungi were isolated and diagnosed, namely T. mentagrophytes, T. rubrum, M. canis, A.niger and C.albicans. By using the comb method, drug sensitivity for the isolated fungal species was tested and the test included fifteen type of antibiotics: Ciprofloxacin,Meropenem,Azithromycin,Levofloxacin,Cefepime,Erythromycin,Linezolid,Clindamycin,Rifampicin,Streptomycin,Ceftazidime,Colistin,Nalidixic acid,Cefuroximeand Amikacin . The results showed that Erythromycin and Ciprofloxacin were the most inhibiting antagonists of T. mentagrophytes , whereas Erythromycin, Meropenem and Ciprofloxacin had the highest effect against T. rubrum . Meropenem, from another hand, showed its inhibitory activity against M. canis , while Azithromycin had the greatest frustration effect on C.albicans yeast and with clear inhibitory diameters. A. niger did not show sensitivity to any antibiotic. The lowest inhibitory concentration of Erythromycin was determined against T. mentagrophytes and M. canis with its value (0.15 and 0.31). The lowest inhibitory concentration of Nalidixic acid for T. rubrum was 0.15 mg / ml, whereas the minimum inhibitory concentration value for Azithromycin for C.albicans was 0.31 mg / ml.