Understanding the Efficacy of Anticancer Property of Methylglyoxal along with Indomethacin

Abstract

Methylglyoxal (MG) is a normal metabolite has long been known for its potency towards anticancer activities byattacking the cancer cellbut without any deleterious effect on healthy normal cells.Thoughthismolecule has been studied since many years against various types of cancer but its degradation by different enzymes existing inside the system is the major concern.The objective of our study is to find out inhibitors of glyoxalaseI, the most potent enzyme for breakdown of MG in order to increase the level of MG within the system. Indomethacin is a non-steroidanti-inflammatory drug (NSAID). The anticancereffect of indomethacin had been known for a long time and has been shown as an inhibitor of glyoxalaseI, and suggested that this anticancer effect might be mediated through augmenting the level of MG. Therefore, in an attempt weexplored the efficacy of anticancer property of MG by using Indomethacin in combination with MGin the present study we observedthat indomethacin has some augmenting effect but at higher level it is quite toxic. Thetoxicity of indomethacin could be moderately ameliorated by methylglyoxal.