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Novel Drug Delivery System can be a major advance for solving the problems related towards the release of the drug at specific sites with specific rates. The need for delivering drugs to patients efficiently and with fewer side effects has prompted pharmaceutical companies to engage in the development of new drug delivery system Available existing drug molecules from a conventional to novel drug delivery system which improves patient compliance , safety and efficiency .They have many advantages which give solution to a problem to the release of drug at specific site. Which is an ideal drug delivery which Cross blood Brain. These include medical application of nanotechnology polymer drug conjugates , liposomes , dendrimer & Agent that coupled with targeting Ligands that recognise antigens . Novel Drug Delivery Systems are advanced in solving the problems towards the release of the drug at specific sites with specific rates. delivering the drugs to patients efficiently with less side effects . Many prompted pharmaceutical companies in the development of new drug delivery systems at a stubborn site . To minimize drug degradation and to prevent harmful side-effects . Increase drug bioavailability and the fraction of the drug in the required zone and drug targeting systems .