Dynamics of Innate Immunity Parameters in Acute Kidney Injury after Coronary Bypass Grafting

Abstract

The problem of acute kidney injury (AKI) after cardiac surgery is still unsolved, despite the high level of surgical technique development, protection of organs and tissues in conditions of artificial circulation. According to different authors, complications occur in up to 42%, and the necessity for renal replacement therapy in up to 1-8%.The purpose of the research was to assess the diagnostic and prognostic value of innate immunity parameters - interleukins (IL) 6, 8, 10, 17 and tumor necrosis factor alpha (TNF-α), growth factors TGF-β1 and matrix metalloproteinases 8 (MMP 8) and its tissue inhibitor 1 (TIMP 1) in patients with acute kidney injury before and after CABG. Blood serum of 120 patients of both sexes with coronary heart disease (CHD) was studied before and after CABG. An increase in the concentration of cytokinins IL 6, 8, 10, 17, TNF-α, TGF-β 1 in all groups after surgery on the first and second days was recorded, changes in MMP 8 and TIMP 1 serum concentrations in patients with acute kidney injury were assessed. The problem of immune disorders in cardiac surgery patients with AKIwas studied. Possible additional predictors of AKIwere identified.