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Administration of chemical substances at toxic doses usually lead to blood parameter alterations, which indicates occurrence of hematological disorders like anaemia. In addition to the positive effects of nanoparticles, they are considered as potential hazardous agents to human's health. In the present study, (24) healthy albino rats were divided into 4 groups, 6 rats for each. The control animals included rats without treatment, while the GNPs group rats received gold nanoparticles. GNPs +AS group rats were co-administrated with a combination of GNPs with Allium sativum. The AS group animals were treated with A. sativum only. Blood parameters were measured to find the negative effects of gold nanoparticles. Results in the GNPs group showed that the hematological parameters were significantly decreased (p<0.05) including the red blood cell count (RBCs), hemoglobin (Hb) concentration, hematocrit value (Hct) and platelet count (PLTs), while the white blood cell count (WBCs) showed a significant increase in comparison to the control group. The co-administration of A. sativum along with GNPs exerted a significant modulation in all hematological disorders. Therefore, these results demonstrated that A. sativum has shown a defensive impact against GNPs induced hematological alterations in male rats.