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colorectal carcinoma (CRC) is one of medical and/or surgical challenge that affect older age persons. One of predominant tumor marker is over expression of CD155 gene. Curcumin in nowadays employed for a variety of human diseases. Aim of study: to demonstrate if curcumin has anti-cancer effect on colorectal carcinoma (detected by reduction of CD155 gene expression) or not. Materials and method: CL40 cell line was prepared in 96 tissue culture plate, the level of CD155 gene was estimated by using RT-PCR before and after treating CL40 cell with 2 µg/ml solution of curcumin. Results: there was significant reduction of CD155 gene expression after treatment with curcumin. Conclusion: curcumin has a potential targeting cytotoxic effect on colorectal carcinoma cells.