Evaluate the Protective Effect of Plantagoovata against the Toxic Effect of Phenylhydrazine on Male Rat Sex Hormones and Sperm

Abstract

      The aim of present study is to evaluate the protective role of Plantagoovata seeds against the toxic effect phenylhydrazine on male sex hormones. 35 animals (Albino male rats rattusnorvegicus) were used. The animals were distributed into 7 groups for each group of 5 rats, randomly as follows: the control group. Group second: rats injected (Intraperitoneal) 40 mg/kg phenylhydrazine. Third group: rat treated with alcoholic extract of P. ovata seeds (100 mg / kg). Group fourth: rat administrate Hemavir at 1ml orally/kg daily. The fifth group: rat administrates phenylhydrazine and treated with the alcoholic extract. Group six: rat administrates phenylhydrazine and haemavir. Group Seven: phenylhydrazine as well as the extract in addition to and haemavir. The concentrations of testosterone, SSH, and ICSH were measured using the TOSOH AIA-360 device of Japanese origin 2019. The finding show the PHZ led to a significant decrease (P ≤ 0.05) in Testosterone, SSH and ICSH levels compared with the control group, while treated with alcoholic extract of P. ovata seeds and the drug Hemavir. Also, other groups indicated a significant increase in testosterone, SSH and ICSH. Also, the microscopic examination of sperm slides shows different changes.