Correlation of Single Nucleotide Polymorphisms of IL4 Gene in Incidence and Progression of Asthma

Abstract

Background: The chronic inflammatory condition known as asthma is characterized by inflammation of the airways, which is produced by a number of different cells and biological components. to investigate whether or not there is a correlation between the polymorphism of the IL-4, IL-6, and IL-18 genes with asthma in Iraqi patients. to determine whether or whether there is a correlation between the polymorphism of IL-4, IL-6, and IL-18 and the severity of asthma.

Method:Patients suffering from asthma were recruited for this study from the Asthma and Allergy Clinic at Al-Zahra Hospital, which is located in the region of Alkut. One hundred people who suffer from asthma were included in this study.

Results:For the purpose of this study, a total of one hundred people with asthma were recruited from the Al-Zahra hospital located in the Alkut province between the months of March 2021 and April 2022. At the same time, a hundred individuals who were considered to be healthy controls were also included in the study. In further study, there should be an increased focus on include a higher number of patients to guarantee a more precise assessment. It is probable that the conclusions of different studies will not align with one another owing to the heterogeneity of the illness, which is a consequence of the complexity of bronchial asthma as a disease. And the statistical power associated with a small sample, which is why there is a need for larger study to show any importance of this cytokine gene polymorphism in bronchial asthma and the involvement of cytokines in the severity of asthma.