Evaluation of antianxiety activity of Linalyl acetate in Swiss albino Mice

Abstract

Context: Linalyl acetate is major chemical constituent of  lavender (Lavandula angustifolia, family-Lamiaceae), the plant extract shows anxiolytic effect in aromatherapy so there are possibility of linalyl acetate have anxiolytic effect. Already known effect of linalyl acetate are anti-inflammatory, analgesic and antihypertensive. Despite a long tradition of use, there was no evidence that phytochemical linalyl alone is responsible for activity. Hence work has been carried out to specify phytochemical linalyl acetate is responsible for anxiolytic effect of lavender.

Objective: Three doses of linalyl aceatae were subjected to dertermine anxiolytic activity on evidence of anxiolytic use of plant extract and to determine the most potent dose of linalyl acetate.

Materials and methods: All doses of Linalyl acetate were evaluated for anxiolytic effect in mice by using elevated plus maze, light and dark apparatus. And for locomotor activity open field apparatus and actophotometer were used. Alprazolam was used as the standard drug.

Results: Amongest all doses, linalyl acetate (400 mg/kg) dose was found most potent.

Conclusion: The current study demonstrates statistically significant dose-dependent antianxiety activity of linalyl acetate.