Association of Follicle-Stimulating Hormone Receptor Gene Polymorphisms with PCOS in Salah Al-Din, Central Iraq

Abstract

This study was conducted on (100) samples of women, including (70) samples of women with PCOS after diagnosis by the specialist of the Women’s Consultation Clinic and Hospital in Tikrit and Al-Alam District - Salah Al-Din Governorate - Iraq, and (30) samples from healthy women Non-affected with the syndrome for the period from November (2021) to February (2022), the ages of women ranged between (17-44) years, the phenotypic characteristics of the affected women included 78.5% suffering from irregular menstruation, 54.2% having acne, 52.8% baldness of the forehead and hirsutism, 74.2% and 95.7% of the women having cysts on the ovaries as well as the weight characteristic, as 28.5% had an increase In weight and 44.2% were obese, and 14.2% of women with PCOS were infertile. regarding the concentration of follicle stimulating hormone, there was no significant difference between the group of women with PCOS (0.450)mlU/ml compared to the group of healthy women whose concentration reached (0.371)mlU/ml. the results of the genotyping of the FSHR gene, represented by the genotypes (CC, CT, TT), which are present in a percentage (29%, 22%, 49%), respectively, and we noticed that there was no significant difference when comparing the value of chi-square (X2 = 2.42) for the repetitions with their tabular value At a significant level (0.05) and a degree of freedom (2) for women with PCOS with healthy women, the study indicates that the critical ratio (OR=0.6875) for the genotype (CT) and the critical ratio (OR=0.9307) for the mutant allele (T) is less than one. We conclude from this that there is no association between the FSHR gene and the incidence of PCOS, and that the (T) allele does not represent a risk factor for the disease, and the results of the association between the FSHR gene and the hormonal variables indicate that the genotype (TT) has the highest value for follicle-stimulating hormone (0.4910), and the genotype (CC) has the highest value for the hormone. Luteinizing and testicular adipose hormone (0.5198, 52.58), respectively, and the genotype (CC) has the highest value for gonadotropin concentration (0.1744).