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The coronavirus disease (COVID-19) is a highly transmittable and pathogenic viral infection caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which emerges in December 2019 in Wuhan, China and spreads around the world at the beginning of 2020. The World Health Organization declares the outbreak a Public Health Emergency of International Concern on the 30th of January, and a pandemic on the 11th of March. On the 4th of March, the Saudi Arabia government orders the full closure of all schools and universities nationwide. Secondary Schools student are more likely to engage in risky health practices related to COVID-19. Their compliance with infection control measures is a key factor to mitigate the spread of the disease. Novel coronavirus-2019 is a highly infectious disease that caused a global pandemic around the world. Lack of knowledge about appropriate infection control practices has caused great concerns for human health, especially in the risk of many communicable diseases .and related to COVID-19 ). Aim of the study: to assess the Impact of COVID-19 virus on the obesity and depression on Population at Saudi Arabia in Makkah Al-Mukarramah 2021. Method : Across-sectional study among Population residents in primary health care center in Makkah Al-Mukarramah was conducted using an online questionnaire designed during April 2021. The questionnaire collected socio-demographic characteristics, depression Symptoms in participants before and during the COVID-19 Pandemic (via the PHQ-9 patient depression questionnaire)and the BMI category changes and weight changes during and before the COVID-19, our total participants were (300) . Results: Show that is a significant correlation between total PHQ-9 and COVID-19 were <0.001 during and before were Range during COVID-19 pandemic 17-24 and (Mean±SD) 21.676±3.416 while T 22.879 followed by before COVID-19 pandemic were Range before COVID-19 pandemic 6-18 and (Mean±SD) 12.055±2.559 Conclusion: Saudi Arabia can win the battle against the disease COVID-19, More emphasis should be placed on education of the Population participants about biological meaning of this infection and relative preventive or future measures. Awareness educational programs should be implemented toward preventive measures of COVID-19. In addition Anxiety and depression levels amongst Population at Saudi Arabia in healthcare were found to be high when assessed during the COVID-19 pandemic Keywords: Impact, COVID-19, obesity, depression, Population, Saudi Arabia, Makkah.