Use of Procalcitonin and Neutrophil to Lymphocyte Ratio in Evaluation of Inflammation in Chronic and Acute Kidney Disease

Abstract

Background: This is a cross- sectional study that included biochemical markers comparative between Procalcitonin (PCT) , and Neutrophil to lymphocyte ratio (NLR) in chronic hemodialysis patients and acute kidney disease patients.

Objective: The purpose of this study was to clarify the diagnostic accuracy of the use of Procalcitonin ( PCT)  and NLR level and to prove the value of these markers in the diagnosis of inflammation in patients with chronic kidney disease and Acute kidney disease.

Methodology: Blood samples were collected from patients with chronic kidney disease and acute kidney disease, then  approximately 5 ml with complete information about the  patients, then the blood separate by the centrifuge  and the serum  was used to measurement the levels of Procalcitonin, and NLR.

Results:The study showed the highest means levels of PCT were found in patients with chronic kidney disease (CKD) (1.82 ng/ml), followed by patients with acute kidney disease (0.49 ng/ml), (P. value=0.0495) .The highest means level of NLR were found in patients with chronic kidney disease (4.35±4.07) mg/L , followed by patients with acute kidney disease (2.78±1.31) mg/L.

Conclusions:that CKD patients had higher levels of PCT and NLR than AKD patients.