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A new coronavirus was discovered in Wuhan, China, in December 2019, itwas found to be the reason behind fatal cases of severe pneumonia and sudden respiratory failure. The pandemic of corona virus disease has progressed as a tremendousthreat to health globally. WHO designated the COVID-19 disease and the associated SARS-CoV-2 virus in February 2020. Although, the respiratory system appears to be principle target of the infection, a few information are available related to involvement of liver and gastro-intestinal tract in COVID-19, that could provokes a systemic infection target a lot of organs in addition of lungs and liver or alimentary tract, especially in elders and those of comorbidity. Studies and papers on histopathology and liver disease in COVID-19 continue to very scarce, therefore, our team aimed revision, collect and summarized the histopathological and other variations in liver architecture and functions that caused by infection with SARS.COV.2. The reviewed studies referred to present histopathological changes accompanied covid19 outbreak. The current review study would help researchers and clinicians to understand the histopathology alteration which can support better planning of management and avoidance of risks in future.