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Background: MDR Escherichia coli (MDR E. coli) has emerged as a serious public health issue in Pakistan and other countries throughout the world, causing treatment failure and a significant health burden.
Aim:The goal of this study was to assess the prevalence and susceptibility of MDR E. coli isolated from patients at a tertiary care hospital of Karachi.
Method:E. coli (n = 439) was isolated from clinical specimens, identified, and tested for antibiotic susceptibility using conventional procedures between June and August 2021.
Results: Of the 439E.coli isolates, the majority were from urine (55%). MDR E. coli were present in 176 (40.1%). Of these, the resistance percentage were recorded to: Gentamicin 60%, Moxifloxacin 15%, Ciprofloxacin 40%, Amoxicillin 20%, Fosfomycin 10% and Ceftolozane/Tazobactum 5%. Female isolates were more resistant than male isolates. The antibacterial drug combination with Fosfomycin demonstrated a significant difference (p- 0.002).
Conclusion: Drug resistance monitoring and epidemiologic analysis of patient data are required on a regular basis and can provide useful information for antimicrobial resistance management.