Prevention of Recurrent Spontaneous Preterm Delivery by Using Probiotics Including Enterococcus Faecium, Bacillus Subtilis, and Clostridium Butyricum: A Retrospective Study

Abstract

Aim: The study aims to evaluate the rate of recurrence of spontaneous preterm delivery (sPTD) in pregnant women that have been administered probiotics

Study design: A retrospective study

Place and Duration:This study was conducted at Ghulam Muhammad Mahar Medical College Sukkur, Pakistan from May 2020 to May 2021

Methodology: The study included a total of 102 pregnant women who had a positive history of sPTD. The participants that had been given probiotics before 14 weeks of pregnancy, were selected in the study. The rate of occurrence of sPTD in 510 women who did not take probiotics, was compared with the participants that had taken the probiotics.

Result: The recurrence rate of sPTD was 14 (13.75%) out of 102 women that had taken probiotics. Compared to those women, those who had not taken probiotics showed a recurrence rate of sPTD was 30%. A total of 153 (30%) out of 510 women hadsPTD (p=0.002).

Conclusion:  It is evident from the results that the administration of probiotics significantly reduced the rate of recurrence of spontaneous preterm delivery in pregnancy. The efficacy of probiotics is more if they are taken before the 14^th week of gestation compared to if they are taken after the 14^th week.