Review .Theoretical study of synthesis and pharmaceutical study of Tetrazine derivatives

Abstract

Tetrazinesareheteroaroaticcompoundswithfournitrogensinasix membered ring similar to that of benzene. There,, are three majorisomers,1,2,3,4-tetrazinee,1,2,3,5 tetrazinee, and1,2,4,5tetrazinee, dependingontheplacementofnitrogensinthering, with1,2,4,5-tetrazine being the most prevalent. Tetrazine synthesized by different pathways  , Tetrazine  application as Antibacterial, antifungal, anticancer, antiviral, antimalarial, and antimicrobial activities are found in several tetrazine compounds. Some hexahydro-s- tetrazines are good analgesics and anti-inflammatories, while 3- arylamino-6- benzylamino-1,2,4,5-tetrazines exhibit significant antimalarial activity. A number of tetrahydro-s-tetrazines have been shown to have antibacterial and antifungal properties, with several 1,4-dihydro-s-tetrazine derivatives possessing antiviral and anticancer properties.