A Review on Recent Trends in Nasal Drug Delivery System

Abstract

Intranasal administration of antihistamines, antibiotics, vasoconstrictors, and decongestants has been used for many years to induce a local effect on the mucosa. These medications have the advantage of systemic bioavailability when self-medicated When compared to oral delivery, nasal administration is more effective. Traditional nasal drug delivery systems, being superior to oral or injection administration, challenge limitations that maximize their efficacy and applicability. The intranasal route has gained popularity as a method for systemic administration of vaccines, hormones, peptides, and other medicines. Intranasal medication delivery, once limited to the treatment of rhinitis and nasal congestion, is increasingly obtaining popularity for the administration of a vast range of medications. Nasal drug delivery alternatives are being considered as feasible alternatives to established systemic drug administration routes. This is due to the nasal epithelium's high permeability, which allows for a greater molecular mass around 1000 Da, as well as the quick rate of drug absorption is often like that of intravenous injections, alongwithplasma drug profiles that are almost identical.