Preventive Effect of Antioxidant, Curcumin, Against Formaldehyde-Induced Neurotoxicity in Rats

Abstract

Our problem is to evaluate the behavioral effects of infection and combination toxicity - infection in adult Wistar rats and the protective effect of an antioxidant (the curcumin) on neurobehavioral alterations and complications. Toxicity was induced by a single intraperitoneal injection of Formaldehyde (FA) at a dose of 10 mg/kg.

The administration of Formaldehyde which is revealed, on one hand, the effects of a single intra-peritoneal injection on anxiety behaviors and the other hand the protective role of antioxidant (curcumin) on FA-induced disorders. Behavioral test in the open field (OF) revealed that animals treated with FA exhibited an anxious behavior and an alteration in locomotive and exploratory activities when compared to control. The curcumin, a natural antioxidant was administered orally (gastric gavages) at a dose of 60 mg / kg. This administration reduces anxiety and the therapeutic benefits of curcumin against the deficits caused by formaldehyde.