Main Article Content
Depression like many diseases is pleiotropic but unlike Alzheimer's disease and cancer it is still largely marked out and falls into the dark shadesfor human illness. Depression is a social stigma which causes failure in the treatment of the disease despite the use of various conventional anti-depressants. The patient undergoes different symptoms such as Sadness, tearfulness, emptiness, or hopelessness. The various depressive disorders mentioned in the review highlight the role of biological differences, Neurotransmitters, Hormones in pathophysiology of depression. The review mentions several anti-depressants used as conventional treatment like SSRIs, TCAs, MAOIs. This review addresses the definition, causes, evaluation, treatment, and the prevalence of repurposing the drug for the treatment of depression. Finally, the review briefly sparks emerging targets for antidepressant drug discovery and the novel effects of rapidly acting antidepressants, without any side effects.