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The nerve regeneration in the peripheral can start after the nerve injury, but in the central nerve the proses is very complex. The nerve injury classified to many types according to the severity on injury. Vitamin B12 have the ability to increase the Schwann cells and accelerate the nerve regeneration and increase the nerve myelin. We have 12 rat divided to tow group each group 6 animals, all the animals have the transaction in the Sciatic nerve and sutured. The control group left without any added and the treated group given vitamin B12 orally 14 days.