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The objective of this work was to study the protective effect of zinc acetate and Zinc Nanoparticles biosynthesized by Aristolochia longa extract against variations in biochemical parameters and oxidative stress in rats exposed to nickel. Twenty female Wistar rats divided into four groups (n=5); Control, Nickel, Nickel + zinc, Nickel + ZnNPs. Nickel (20mg / kg feed), Zinc (231 mg/kg feed) as ZnSO4 7H2O and ZnNPs (100mg/kg feed) were added to the feed of the animals in groups for 20 days. Results show. In this study, there was also a significant rise in relative liver and kidney weight (p<0.05)., blood glucose, lipid profile, urea, creatinine, uric acid concentration transaminases and a considerable decrease (p<0.05) in body weight gain in rats contaminated with nickel compared to control. The results also revealed an increase in liver Ni, tissue MDA and a decrease in liver zinc, tissues GSH and SOD levels. The addition of zinc and zinc nanoparticles to the diet of rats exposed to nickel partially corrected previous parameters. The experiment demonstrates the great effectiveness of zinc, especially in the nano- form bio-synthesized by Aristolochia longa extract, in reducing the toxic effects of nickel on the liver and kidneys of rats.