Genetic Analysis of Growth Hormone (GH1) Gene in Three Indigenous Goat Breeds of District Larkana, Sindh, Pakistan

Abstract

Pituitary growth-promoting cells, located near the base of the brain, generate growth hormone protein, which is encoded by the GH1 gene. Bone and tissue development is dependent on growth hormone, which is produced by the pituitary gland. Growth hormone is inhibited or hindered by GH1 gene mutations. Insufficient levels of growth hormone cause the body to grow more slowly, resulting in short stature. Using DNA sequencing and PCR gel electrophoresis, researchers found six GH-1 gene variants in each of three goat breeds: Sindh Desi goat breed (03), Tapri goat breed (02), and Kamori goat breeds (03). (01). Point mutations in the genetic code are those that affect only one gene, such as mutation 03 in Sindhi goats, mutation 02 in Tapri goats, and mutation 01 in Kamori goats. According to this research, the Sindhi goat's meat qualities are enhanced by the breed's unique DNA sequence.