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Present study was designed to explore the anti-acne and anti-inflammatory potential of ethanolic extracts and fresh juices of different dietary and nutritive fruits. The Disc Diffusion (DD) and Minimal Inhibitory Concentration (MIC) methods were used for microbial analysis of all tested 95% ethanolic extracts and fresh juices against four strains (S1, S2, S3, S4) of Staphylococcus aureus. Anti-inflammatory assessment was done through skin irritation and dermal toxicity test for active extracts and fresh juices by using albino mice. Pomegranate peel extract, pomegranate arils extract and fresh lemon juice substantiated as more effective and competent anti-acne agents with growth of inhibition zones up to 24 mm, 17 mm and 18 mm respectively. As well as pomegranate peel extract showed minimum inhibitory concentration at 10% whereas both pomegranate arils extract and fresh lemon juice showed minimum inhibitory concentration at 20 % with anti-inflammatory competency by showing no edema and erythema.