Gut Microbiome Association with Chronic Inflammations in COVID-19 Patients

Abstract

Objective: To investigate the role of Gut microbiome in correlation with corona virus disease 2019 (COVID-19) pandemic and variation in severity of symptoms induced by inappropriate immune responses.

Methodology: Analysis of different peer reviewed literature from prestigious journals on gut dysbiosis and the variation in disease progression of Covid-19 infection during the current pandemic has established a strong correlation. Our aim is to highlight the quantitative importance of metabolites (released by gut microbiome) for optimal cellular level functions against different disorders and diseases, especially secondary chronic infections and inflammations in post Covid-19 patients.

Results: Four themes emerged: (i) Intestinal dysbiosis can lead to prolonged hypoxic conditions during Covid-19 infection (ii) Diabetes (associated with intestinal dysbiosis) induces poor prognosis in patients with Covid-19 infection (iii) Co-morbidities associated with Covid-19 can be fatal (iv) For immune cells to acquire sufficient metabolites consumption and establish a more formulated and appropriate response, the diverse and abundant microbiome is a primary and prerequisite feature.

Conclusion:  An existing Inflammation in the body is the leading cause of individual’s poor prognosis in case of viral infections. Especially in the light of current pandemic, serious considerations should be taken into account for minimizing the risks associated between covid-19 and pre-existing inflammation in populations and therefore, probiotics might play a significant role in treatments of such conditions.