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One of India's great cultural legacies is the Siddha system of medicine. Most chronic disorders are healed in the Siddha system of medicine by medications made from metal and mineral products, such as Parpam, Chendooram, and Chunnam. In this study, antibacterial activity of some clinically used herbs-mineral Siddha drugs such as Kungiliya parpam, Vengara parpam, Padikara parpam and Silasaththu parpam was investigated against clinically important standard reference bacterial strains (ATCC- American Type Culture Collection) such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. In Indian medicine, these siddha formulations are used to treat a variety of diseases. The disc diffusion method was used to test the antibacterial activity of siddha formulations. To standardise the antibacterial activity test, 5 mcg of levofloxacin was used as a control. Levofloxacin is used to treat infections like pneumonia, kidney infections, prostate infections, and skin infections. The findings revealed that Vengara parpam and Padikara parpam have antibacterial activity against all clinically important standard reference bacterial strains. Antibacterial activity of Kungiliya parpam and Silasaththu parpam did not show antimicrobial effects against any of the bacterial strains. These herbo-mineral siddha formulations may be effective as an alternative medicine in the treatment of numerous diseases, according to a study.