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Periodontitis is treated by sub antimicrobial drugs like Chlorhexidine, Tetracycline and doxycycline. Patients suffer in taking drugs. Periodontitis is the bone destruction in the periodontal cavity along with gingivitis. There is also the presence of matrix metalloproteinases especially salivary collagenases and gelatinases in periodontal disease. Recently, periodontitists are focusing metalloproteinases for treating the bone destruction with the gingival inflammation. By using the drugs, the effect of MMPs was reduced to an extent. Alprogen ,a single component in aloe vera plant has remarkable effect on Periodontal disease .An attempt was made to study in Periodontal disease comparing with the regular drug of choice.