A Novel Method For Spectrophotometric Method Development And Validation For The Estimation Pregabalin In Pure Form And Tablet Formulation

Abstract

A simple, accurate, cheap and quick spectrophotometric method was developed for the estimation of pregabalin in pharmaceutical pure and dosage forms. The method was based on the methyl orange reaction with drug pregabalin. This reaction produces a purple colour. The absorption of the pregabalin-methyl orange complex at 506nm had a linear relationship with the pregabalin concentration ranging from 10-50 μg/ml. The %RSD was less than 2%, showing high degree of precision of the proposed method. The methods were satisfactory applied for the determination of drugs in both bulk and pharmaceutical dosage forms. The colorimetric pregabalin assay reported herein is of great practical value because it is reproducible, sensitive, simple and extremely inexpensive.