Aninvitro Antibacterial and Anticandidalactivity of a Phytomedicineperillafrutescence (L.): A Future Herb for the Development of New Antimicrobial Drug

Abstract

A herb of interior and remote villages ofUttarakhandPerillafrutesenceis scientifically investigated first time in view of its traditional uses and folklores in treating various diseases and microbial infections.

In this study the chemical composition of the Perillafrutesencewas analyzed and the antimicrobial activity of different solvents from different parts of the plant was determined.The antimicrobial activity was detected in flower  and seedextracts. Chemical composition analysis of seeds and flowers with GC-MS indicated the presence of saturated and unsaturated fatty acids.The plant seeds extracts presents12.11area% of saturated fatty acids and 19.04area %of unsaturated fatty acids while the flower extracts contains17.89 area % saturated and 2.15 area% of unsaturated fatty acid.The antimicrobial activities were performed using the agar diffusion methods.The flower extracts was active against Staphylococcus aureus (ATCC-6538),E.coli(ATCC-8739) and Candida albicans(ATCC-10231) followed by seed extract in concentration of 100 µl while pure fatty acids Linoleic,Linolenic and oleic acids were active against all test organisms in a concentration of 10 µl.

The results indicated that Perillafrutesenceshowed antibacterial and anticandidal activities and may be a promising potential candidate for the development of new antimicrobial  Phytomedicine.