Study the Correlation between Immunohistochemical Expression of TNFα and IFNɤ with Development of Prostate Cancer and BPH

Abstract

Background: Prostate diseases are the prevalent age-related disease of the male. Chronic inflammation strongly associated with both benign and malignant conditions of the prostate that leads to accumulation of immunocompetent cells which secret various cytokines that provide the suitable environment for various disease progression specially cancer

Objective: Evaluation of TNFα and IFNɤ immunoreactivity in prostatic carcinoma and benign prostatic hyperplasia (BPH) and to correlate this expression with clinicopathological parameters.

Methods: A case control study of 120 paraffin embedded prostatic tissue blocks, 50 cases were prostatic carcinoma (PCa), 50 cases were benign prostatic hyperplasia (BPH) and 20 cases were normal prostatic tissue. Sections from each block were prepared for immunohistochemical staining of TNFα and IFNɤ.

Results: Negative expression of TNFα were observed in 18 (36.0%) out of 50 cases of BPH and positive expression were observed in 32 (64.0%) out of 50 cases of BPH, While the Pca cases revealed positive expression in 44 (88.6%) and negative expression were observed in 6 (12.0%). The results showed that 40 cases (80.0%) of BPH showed negative expression of IFNɤ, and 10 cases (20.0%) showed positive expression.On other side, the results showed that 26 cases (52.0%) of Pca showed negative expression of IFNɤ, and 24 cases (48.0%) showed positive expression.

Conclusion: This study concluded that there were differences in expression of both TNFα and IFNɤ between prostate hyperplasia and prostate cancer tissue by immunohistochemistry.