Association of IFN-α Receptor Promoter (IFNAR1) Gene Polymorphism with Multiple Sclerosis in Iraqi Patients

Abstract

Seventy Multiple sclerosis (MS) patients and fifty apparently healthy as a control group. The result of current study showed the mean serum level of IFNAR1 was higher decreased significantly (P ≤ 0.01) than in controls (791.6131 ± 544.066 pg/ml vs. 1352.995 ± 491.2842 pg/ml) respectively. Blood samples were used to extract DNA. Detection of genotypes IFNAR1 18417 were performs by RFLP-PCR. The distribution of the observed IFNAR SNP 18417 genotype and alleles frequencies in the case group heterozygous CG genotype frequency was highly significantly increased in patients compared to controls (52.9%) and (14%) respectively; OR = 0.1892; CI (95) = 0.0760 - 0.4708). The genotype of (GG) was highly significantly decreased in patients compared with control (45.7% vs. 82%); respectively; OR = 5.409; CI (95) = (2.2864 - 12.7996). The present study shows that the presence of IFNAR1were significantly associated with genotype of IFNAR1 (18417) (GG, CG, CC) among patients and control at (P ≤ 0.05). The present results showed the CC and GG genotypes of IFNAR1 (18417) gene were revealed that the risk of MS among cases than control. It’s possible that this has a predisposing impact on the development of MS.